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Natular® Larvicides

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Length of Control

Residual, Single Brood

Formulation type

Granule, Liquid, Tablet, Water Soluble Pouch

Labeled Treatment Areas

Certified Organic Areas

IRAC Mode of Action

5 NACHR Allosteric Activator

Active Ingredient

Spinosad

Product Details

About Natular®

Introduced in 2010, Natular® is like no other mosquito larvicide in the world. With formulations developed and manufactured exclusively by Clarke, its patented active ingredient, Qalcova brand spinosad, is a product derived from a naturally occurring soil bacterium that provides the right balance of efficacy with environmental stewardship. 

Natular formulations are designed to meet the treatment needs for a wide range of environmental habitats, and are excellent rotational product options for responsible resistance management.  Most Natular formulations (except Natular DT, designed specifically for containerized water sources) are OMRI Listed for use in and around organic farms and gardens.

  • First IRAC Class 5 Larvicide 
  • Five WHO PQ Listed formulations
  • First U.S. EPA Reduced Risk Larvicide

Natular is the first public health larvicide in the IRAC Class 5 chemical classification, delivering a unique mode of action that works on all four stages of mosquito larvae. It has been tested to demonstrate efficacy on twenty of the most common vector and nuisance mosquito species, including Aedes, Anopheles and Culex. This makes it an excellent tool to suppress mosquito populations before they hatch while helping avoid or fight resistance.


Natular Formulations Review

Natular is a mosquito control product for use “Where Public Health Meets Public Preference.” The Natular line of larvicides includes eight different formulation options to fit a wide range of habitats. Each formulation type offers exceptional handling characteristics and proven, reliable efficacy.

Note:  The Natular brand and formulation names may vary across different countries outside of the United States, in order to comply with local regulatory or trade requirements. For questions about Natular registrations in a specific county, please contact your local Clarke representative or our Customer Care team.


Natular and the Environment

Spinosad was the first mosquito larvicide active ingredient registered under the EPA’s Reduced Risk program due to its reduced risk to human health and non-target organisms when compared to other available alternatives. Spinosad is of low acute and chronic toxicity to a wide range of non-target species, including mammals, birds, terrestrial wildlife, and fish.

Clarke earned the 2010 U.S. EPA Presidential Green Chemistry Challenge Award for the tablet technology it developed for use with Natular. This prestigious award recognizes outstanding chemical technologies that incorporate the principles of green chemistry into chemical design, manufacturing and use, and that have been or can be utilized by industry in achieving their pollution prevention goals.

Spinosad in Soil

Spinosad degrades readily in the soil environment and is non-persistent. Exposure to sunlight accelerates the degradation process.

Spinosad in Water

By design, larvicides are intended to be applied to standing water sources to prevent mosquito breeding for a specific length of time. As an active ingredient, spinosad degrades rapidly in water, with exposure to sunlight and presents a relatively low risk to beneficial and non-target insects when compared to other broad-spectrum insecticides. Under laboratory conditions, spinosad is toxic to some aquatic invertebrates, primarily upon chronic exposure. Fortunately, the rapid degradation of spinosad in natural aquatic environments prevents the long-term exposure that would be needed for these effects to occur in real-world situations.

Spinosad and Animals

When applied as indicated on the label for control of mosquito larvae, Natular will not endanger human or animal health. Spinosad is not toxic to mammals. Spinosad is not carcinogenic, not genotoxic, and is not a reproductive or developmental toxin.

Spinosad and Pollinators

The EPA has determined that when liquid Natular products are used according to label directions, they should not pose a significant risk to honey bees or pollinators. Spinosad in liquid form has been used extensively in more than 85 countries with over 250 registered crop uses since its first launch in agriculture without any reported adverse effects on bees. Granular and tablet formulations of Natular will not pose a bee hazard given their application method.


Applying Natular

Natular larvicides are available in eight different formulations, all designed for different habitats, lengths of control and application methodologies. Please refer to each product label for specific application guidance, but generally, Natular formulations may be applied by air, through air blast machines such as a Buffalo Turbine, through a backpack and/or by hand.

Frequently Asked Questions

What is the active ingredient in Natular® larvicides?
Spinosad. It is a naturally derived active ingredient produced during fermentation by the soil organism, Saccharopolyspora spinosa. The natural metabolites produced during the fermentation process were termed “spinosyns.” Spinosad is the collective term for the two most prominent and most active compounds in the fermentation broth (spinosyn A and spinosyn D). Hence the name “Spinosad.”

How is Natular’s active ingredient spinosad manufactured?
Spinosad is produced in a state-of-the-art fermentation facility in the United States, using natural feedstocks to maintain the fermentation process.

How does the active ingredient in Natular formulations control mosquito larvae? 
Spinosad has a novel mode of action; it alters the function of insect nicotinic acetylcholine receptors in a unique manner. Ultimately paralysis sets in upon ingestion and contact and the mosquito larvae don’t recover.

What are the inert ingredients in Natular?
All inert components in domestic Natular formulations are included in EPA’s list of Minimal Risk Inert Ingredients. Inerts are non-synthetic (natural) or are synthetic components which do not contribute to mammalian or aquatic toxicity.

Are Natular formulations suitable for use in organic agriculture?
Most formulations of Natular registered for public health mosquito control with the US EPA are listed by the Organic Materials Review Institute (OMRI) for use in and around organic agriculture. Natular DT, which is designed to control mosquito breeding in containerized water sources, is not OMRI Listed, given its highly-targeted, contained use pattern.

Is Natular a resistance management tool?
The active ingredient in Natular products, spinosad, is the only active ingredient currently used for mosquito control that is designated by IRAC (Insect Resistance Action Committee) as Group 5. The benefit of this is that it has no cross-resistance with existing products – making Natular an excellent option for resistance management.

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Our fundamental job is to discover and design the most effective mosquito control products of the future, and ensure the performance we can achieve in the lab translates to real-world operational excellence for customers.

Yemi Susan Bullen-McClain, Ph.D
Director, Product Innovation & Field Sciences

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